If you use the information on a box of factory ammo, it's easy to convert KE to Momentum (a much better measure of effectiveness of a bullet on big game). Simply divide the KE by the velocity and multiply the answer times 2. Hornady used to have a momentum-based power measure in their website in the ballistic tab, but changed an easy calculation to a messy one.
The 480 Ruger has 20% more bone-breaking momentum than the 460 S&W because of bullet diameter and weight advantages even with 500 fps less velocity. The Super Redhawk weighs much less than the S&W biggest handguns. Someone also sold 5-shot Ruger SBH revolvers in 480, but I'm not sure I'd want to shoot one very often.