Mil-Dot gets my vote, and mil-mil not mil-moa... They can be used for any caliber in combination with a good ballistic program... I have the Strelok on my smart phone and Strelok has over 500 reticles in their data base on the premium editon.. I have a couple of SWFA's with mil-mil on a Knight .45 inline shooting a 400 grain paper paatched bullet and the other is on a 300 WinMag shooting a 185 grain Berger... both can hit the target if I do my part... of course I spend some time on the range verifying the velocity and POI to the calculations...I'm an old codger and don't shoot as well or as much as I used to... wish I had one of these scopes and programs when I was a serious ground hog hunter back in the 60's.