i have seen this all the time and i cringe. guys walk into the local sporting goods store and buy 100 primers, maybe 200...the big timer buys 1000...a box of 10 primer trays with 100 in each.
guys buy powder by the lb..........
ok, here is the deal. primers vary from lot to lot, when you change lots of primers you need to retest your load, probably re do your load. when you change lots of powder, you need to recheck you load. lot to lot variation is well known. not dangerous in most cases, but will change what you thought was a great load to patterning like a shotgun.
if you have a gun you shoot alot...the throat will wear and you need to move the bullet out and add more powder....(not so much with boolits).
more to come