i have a ruger gp-100 6" and load for both 38spl and 357mag, with 90% of the time using 38spl rounds and target loads of bullseye under my cast 150 grain 1:20 alloy bullets that are gato feo lubed. never had any cylinder crud build up. guess it's all a matter of load, alloy and lube, with firing 38spl in a 357mag cylinder.