wrong powder wouldn't do it.
I have loads for my 12 ga that use titegroup, and loads that use bulls-eye.
so even screwing up and putting 17.?grs of titegroup instead of 17.?grs of titewad wouldn't cause a gun to blow up.
now you could be using green-dot [at like 19grs] and pour in some titegroup or solo-1,000 and have too much powder.
would it disintegrate just the chamber area on a proof tested shotgun???
I doubt it.