Hope this is in the right spot, fell free to move if its not....something happened the other day that jogged a memory from deep in my foggy mind. A good friend works weekend as a butcher, they had a buffalo get out of the holding pen and run across two and into a back yard. My buddy had only his carry gun on him a 9mm pistol and his woodchuck gun a .243 model 70. After some attempts to coral the agitated bison he dispatched it with one round of soft point .243 said it dropped like the rug had been pulled out, between the ear and eye at about 40 yards. It made me remember as a young marine in on a float to a nasty place we did some training in Spain, a truck hit a bull a very large bull who was probably mad at the best of times well now he was furious spittle and bawling a platoon mate of mine we called him swamp rat; thing swamp people on history channel, he said " I can put him down on the spot, he was given a full mag, stood on the hood of a Humvee and with one round to the top of the head at about 65 yards....DRT. Neither of these stories involved cast boolits but the point is shot placement trumps all other considerations and variables. .5.56 nor .243 is by any stretch "Buffalo"guns but cool hands with a rifle won the day.