I used to drink the 45-70 kool aid and while it is a good cartridge, there are certainly better ones. For big animals, the 50-70 hits harder and has a bit less recoil. For smaller stuff, the 405 WCF (or if you want a bolt rifle the 40 Whelen or the 411 Hawk) hits harder and flies flatter than the 45-70.
That said, the 30-06, properly loaded, is suitable for anything on North America. Look at some of the loads for the 220+ grain boolits.