Shooting 350 to 450 grain bullet much past 1,500 fps out of a 45-70 levergun will produce nothing of value in the hunting field. You can't turn the 45-70 into a flat shooting rifle and a decent cast bullet going the above speed with shoot through and through, from any angle, any game animal in North America.
Any extra powder past that point is just going into blast, fire and recoil with nothing real to show for it.