I am familiar with the Lyman 577-611 minie boolit mold. You can power that minie way up without blowing the skirt.
How is it with Lee's 578-478-M? Does it have a heavy skirt? What charge could you put behind it without blowing the skirt? I shot 100 grains of 2f behind the 577-611 in an 1853 Enfield with very good results. My 1861 Enfield went to 90 grains and going beyond that really didn't add any velocity.