In post #15, 4th paragraph, I state that my loads are slightly compressed. However, it's still a good idea to emphasize that smokeless duplex loads NEED to be compressed for best performance. As Turbo1889 comments, a compressed duplex load is likely to give more consistent ballistics than an uncompressed single powder load. My 45-70 loads give 10 fps average deviation.
In my experience, no matter the boolit weight, you can't possibly stuff enough WC-860 in a 45-70 or 38-55 case to generate excessive pressures. The only way you'll get high pressures is by using too much ignition powder. I find that 3.0 grains in a 45-70 & 40-65 or 2.5 grains in a 38-55 is enough to do the job. The only danger is a double charge of the fast powder. I'm very careful and double check to make sure I don't do that.