I for one have no pat answer!
Meplat is VERY important but from what I have been seeing, there is an optimum velocity range.
My .44 with the hard cast WLN (320 to 330 gr) at around 1316 fps destroys lungs and blood pours on the ground, deer seldom make 30 or 40 yd's.
The .45 Colt busts deer as good with heavy, hard cast WLN or WFN boolits (335 to 342 gr) going 1167 fps.
The .475 is best of all at around 1340 fps and either the WLN or WFN (400 to 430 gr) just smashes deer, most hard put to make 20 yd's.
The best part is that internals are destroyed but meat damage is mild and just a little trim is needed around the holes.
As soon as I get over 1600 fps in the 45-70 (317 to 378 gr), things change drastically with little blood sign, sometimes no blood on the ground for a long distance, deer going 100 to 200 yd's. An 80% meplat did not help. Too many deer tested to make me want to try another.
What happens with a WFN, hard cast at 1800 to 2000 fps?
Sure, shoot the deer at 200 or more yd's and they become killers again but what happens to the 30 yd deer? How many guys would revolver hunt at 200 or more yd's?
We have much to learn and I have been doing the testing on animals where it counts. Theory and shooting into test media proves nothing.
Some are just going the wrong way looking for faster and faster boolits, after all, flat trajectory with a revolver is a silly thing to look for unless you are shooting targets.
It is better to look for heavier boolits at the correct velocities to make use of a large meplat and gain penetration.
As far as nose angle I firmly believe you want a good fit to the forcing cone and forget about it's effect on boolit flight. The boolit needs to stay straight when it impacts the cone. That is why I do not like the Keith because the first thing to hit is the little shoulder. The nose provides no guidance.
Accuracy??? I can keep all of my 45-70 revolver boolits on a ram at 500 meters by aiming at a tree branch 26 or more feet, depending on the boolit, above the ram using a red dot. Does the WLN or WFL shoot poor at range? Can't prove it by me!
Killing power at the higher velocity---ZILCH, need expansion to slow it in the animal. Notice guns like the .454 and .460 depend on jacketed bullets to kill. Too fast for hard cast. They need heavy boolits slowed down and is why a .45 Colt will do the job as well once the .454 and .460 are slowed down.