I like 2.5 grains of Red Dot behind an Ideal 313445 sized 0.313" lubed with FWFL in my little 4¼" I frame. Velocity was in the low 700's, and straight ACWW was too hard for good use as a varmint cartridge. The possum wasn't very impressed, and neither was I.
That mold is such a pain to cast decent boolits with that I have since switched to using the RCBS 98 gr SWC. I haven't ran any of them over the chronograph though.
Robert