I have generally been using 2400 and 4198 but have good luck pushing the velocities, so I tried H322 and RL10x and have some A2015 I'll try soon. My theory is that slower powders give a gentler start to the boolet and reduce the blow by in the throat. This is a special concern with the 311467 ~177 gn Loverin which has a very small first band above the GC.
I'm slowly increasing the amount of 2400 and 4198 I use too and seem to be getting better groups in my Krag and .308 R77. (155 to 200 gn boolets) I've worked up from 16 gn 2400 to 19 gns and 20 to 25 gns on 4198 and groups are better, noticed that there is a point where the powders, "Get on the step" with much increased velocities per grain of powder, and tighter groups. Had been shooting 1600-1750 fps but the higher loads pushing 1900 fps.
When I tried H-322 and RL10x, I started getting over 2000-2200 fps! (~30-35 gn) Plus no leading! And good groups so far.
Have I just been too conservative? I don't want to blow up a gun and just need best accuracy but would like better power for 200 yard Rams in my cast boolet shoot.