I have a Friend that bought a Uberti 1866 copy when they first came out in .45Colt, almost 30yrs ago. His standard Cowboy Shooting load is 8.0grs of Unique under a 230gr TC for Revolver and 255gr RF for Rifle.
He probably averages 3,000 - 5,000 rounds a year.
I've probably shot half again that much in my Uberti 1873 Clones from 1987-2010. A .44-40 that I shoot a load of 225gr RF over 6.0grs of Titegroup. Used to use Unique until I switched after Titegroup came out, just a bit more economical, better for the cold at Winter Range.
And My Uberti 1866 clone; I've put about 3,000+ rounds of #454190-260gr over 9.0grs of Unique. Plus thousands of My STD Cowboy Load of 225gr TC over 5.0grs of Clays.
After 33+yrs of Uberti rifles with a toggle link action ? I think they will last a long time.
Just don't abuse them, too much.