One aspersion that is complete rubbish as far as I am concerned regarding cast boolits is they "foul up the barrel." To this I reply that so do jacketed bullets, and copper fouling is 10x harder to remove.
The vast, vast majority of rifles I've bought used that were shot were caked up with copper fouling to the point their accuracy was diminished. This is a common phenomenon with new barrels as they aren't smoothed up yet, and it is one of the reasons I like to buy used.
Copper fouling has to be removed chemically by toxic, foul smelling, corrosive solvents that are unpleasant to use and expensive. They are also all corrosive to the point that if they get into places you don't want them they will do damage. Lead fouling if not too bad is so easily removed as to be trivial. Sometimes I get a little and just push a bronze brush and some hoppes 9 down the barrel and it's gone...along with the carbon. If it's really bad a copper chore boy and bronze brush is used. Still it takes a fraction of the time and hoppes 9 is nothing like Barnes CR10 or Sweet's 7.62 which are needed to really remove copper.
For handguns and straight wall rifles it is my contention that cast bullets perform as well or better than anything jacketed. It may take a little fiddling, and it is true that JHPs in handguns have a slight advantage as far as terminal ballistics go (due to the toughness of the jacket allowing a greater range of impact velocities where the bullet will perform well) but if you handload and are basically a hunter it matters little. You can adjust velocity and hardness, etc. to suit the task.