I Agree with outpost 100%. 44-40 or 44 special with 200 to 220 gr at 900 to 1200 fs is plenty for any deer. I have also shot some with a 180gr 38-40. In my 44s i have settled on the Lyman 429215 hp cast of 95/2.5/2.5 alloy. It expands well and penetrates clear through on broadside shots.