I'm guessing you were directing your advice to Abert Rim, as I am using 250 grain boolits.
I was trying to advise Abert to go with a slower burning powder for mid power loads, rather than Universal.
Maybe not as slow as H-110/296, but something in between.
Abert is talking about using a 322 grain at 1000. If he has a large frame Bisley ( I'm still not sure what Bisley he has) it should be able to handle it, but I am in agreement, Universal is a bit fast burning for that. Universal or Unique seems to build up pressure rapidly at the higher end charges.
I used a 335 grain Cast Performance in my large frame Bisley getting 1200 fps. But I used 21.0 grains of W296.
It wasn't a load that I shot a lot, but was my carry load when I lived in Grizzly country.
Myself, I only want to go slightly higher than a mild Cowboy load so as to have the brass seal better in the chamber.
Those mild Cowboy loads tend to blacken the case on one side.
Maybe 9 grains of Universal, or 10.0 grains of HS-6 will get me there, and result in less smoking up of the case, while still being pleasant to shoot, and safe in my mid frame .45's.