IIRC, wax bullets will go through garage door, no problem. Other is powder choice, cfeblk is supposed to be flash suppressed. I can't shoot my 10" pistol with one hand and it only has 3 more rnds than my 40. Don't think an intruder is going to stick around for a gun fight.
shotgun with light bird shot - ever see what a 20ga dove load @ 20ft will do?
The question posted - and my answer is if it's not good for a 'carry' gun it's probably not the best for 'in house' protection as the scenario would be approx. the same. The other problem is kids around the house, with gun access. You got to figure that one out yourself.