I haven't tried the Lee 160gr TL boolit in my Enfield but have used it in my 1891 Argentine Mauser and Mosin Nagants. In the Argentine Mausers it shoots very well with 12 grs of Unique. In the MN I use 20 or 21 grs of Alliant MP300.
In the very worn or corroded barrels a 1 gr tuft of poly-fil helps with accuracy. I have an old 1917 Enfield 30-06 that takes .315" boolits but you can barely hit a 4' 100 yard target without the poly-fil. About 4" to 6" with the poly-fil.
I have a Savage Enfield that is pretty worn and a very good condition #4 MKII I will have to break out soon and play with.