Usually the slower the twist rate, the shorter the conicals need to be in order to shoot accurately.
In most cases, shorter bullets means lighter weight bullets.
It's often better to shoot conicals that are lighter weight and short than bullets that are too long and heavy to stabilize.
Of course this is only a generalization since any bullet can possibly shoot well with any twist.
Sometimes it depends on the size of the powder charge which affects the RPM's of the bullets when fired.
The same rule often applies to bullets fired with sabots which can offer a greater variety of bullet weights, some as light as 225 grains or less.
For instance MMP sells .50 sabots that allow either .44 or .45 bullets to be loaded of which there are some light weight ones to choose from.--->>>
https://mmpsabots.com
The old 245-250 grain Buffalo Ball-ets would shoot close to the point of aim of a .50 patched round ball.
Since Buffalo Bullets moved to Nevada, people have been waiting for them to restart Ball-et production.--->>>
https://buffalobulletindustries.com
The Hornady Pennsylvania .50 Conical that weighs 240 grains is very similar to the Buffalo Ball-ets and works with a variety of twist rates from fast to slow.
It has a lot of favorable reviews on the MidwayUSA website.--->>>
https://www.midwayusa.com/product/73...rain-box-of-50