I doubt that Bullseye is any different than it ever was. Loading data on the other hand is tested differently than it was in the past, so some of the numbers have gone down. As always start at the starting loads and work up because individual firearms vary.
Clays is a great powder and very clean in the 44spl. About 12 years ago I worked up to 4.0gr with a 240gr boolit for 600fps and accuracy as good as you can hold. (But how much does your 44-250-kt actually weight? The used mold I purchased 3 years ago drops at 260gr.)
As far as Titegeoup, I don't like it in my double action revolvers. I bought a lb and loaded up equivalent power/velocity to my favored 150gr loading of WST in 38spl. What I found when practicing with it was how hot my forcing cone and frame got compared to WST. (My fingers slip into that area when the gun shifts to my LH and I drop the empties with my lh thumb.) There is something going on there I think. Also multiple reports of issues with TiScan guns and erosion out there that I do believe after my experience. My 696 is too cool to me to risk experimenting with.
Currently I use unique or power pistol in the 44 spl. If I wanted a faster powder I would play with either Bullseye because of all the data/experience out there or I would work Clays up from starting loads because of how much cleaner it is than Bullseye.
Regards - Slughammer