Some of us are dealing with pretty severe joint or similar pain. With the crackdown on opioid pain medications and just the way most pain meds become less effective over time this alternative seemed worth posting. Like that it is specific to the pain nerve, no withdrawal or addiction issues, no constipation, no tolerance built up requiring larger doses. Not playing hob with liver or kidneys.
https://www.wired.com/story/resiniferatoxin/
Apparently this cactus produces a substance that is 10,000 times hotter than the Carolina Reaper which is the hottest pepper. When an extract from this cactus is applied to nerves that are transmitting pain it essentially burns them out. Applied to a damaged joint via an injection one has to be sedated for the treatment and until the burning pain declines but for extended period measured in months following the treatment the nerves for pain will be knocked out. However not the nerves for touch or position etc. so one doesn't become numb just can't feel extremes that would register as pain.
Which does lead to the concern. Without pain you may have a hard time being aware of things such as being too close to a space heater that is burning your skin or scalding hot coffee or molten lead. Some physical actions signal limits being reached with pain. Such as lifting something too heavy or applying too much force. If done for say arthritis in the hands you can see how you might not know you broke a finger if you didn't feel any pain. You are still be able to feel touch for example to do reloading, the sense of touch isn't damaged.
Some diabetics with neuropathy that leaves them numb all the time deal with this lack of ability to be warned by pain, and it does take paying attention and self examination to avoid injury.
I guess in the harsh environment the cactus grows in food and moisture are scarce so thorns were not enough deterrent, alternative was to become the hottest most pain inducing substance on the planet which should keep anything from eating more than one bite.