I bagged a full sized mulie doe last night with a big boolit out of the .30-06 (198 grain lubed and checked with a huge meplat). After skinning, I would say that the boolit was pretty destructive, with lots of blood shot meat around the entry wound. The boolit did not hit any bones (aside from maybe a rib), but there was a ton energy transfer with the big meplat and complete penetration was no surprise (the lead probably would have continued to the next county if not for the hillside behind the doe).
No complaints given that the doe made it less than 25 yards from where she was hit, but I wonder if a smaller slug would do the deed with less meat damage. I cast the Lee 150 flat nose and have an accurate load doing around 2000 FPS courtesy of 25 grains of 2400. Is this enough horsepower for a 100 yard shot on a mulie?