Highly likely you've got a thou or so of frame crush at the back of the barrel. I've seen this on a goodly number of Rugers and Smiths, including my .45 Colt /ACP Redhawk which I've yet to get around to fire-lapping the problem out of. In my case, it leads a little bit with my standard 230 gr Ranch Dog tumble lube bullet rolled in Ben's Liquid Lube (pretty dry stuff), but not at all with conventional groove slugs filled with Ben's Red (pretty squishy beeswax / grease combo).