A .45 Colt with a 255 grain wadcutter at 950 fps will flatten most anything on earth
I am going subsonic and heavy with most everything with great results. Yes, I have JSP at red-line speed to reach out if needed. You can easily get out to 100, even 200 subsonic, easily. My new motto, go heavy, go slow. A 170 grain Lee .30 caliber with a low dose of Unique will smoke medium sized game as noted.