Lot's of good input here.
I'll toss in my $0.02 worth:
I gave up on giving woman advice on how to carry a handgun. I show them what is available and let them choose. I DO NOT like off body carry, such as a purse or bag but that seems to be popular for woman. I think off body carry is full of danger.
A single action semi-auto pistol is a proven tool but as others have pointed out, it requires dedication and LOTS of training. Most woman are not willing to put in that time. I would not want a SA pistol rattling around in a purse. For that matter, I wouldn't want ANY handgun rattling around in a purse. At a bare minimum the purse needs to be designed to carry the handgun and be secure.
A DA revolver is a fine self defense tool and about as simple as it gets. Under stress, Simple is Good !
Some woman lack the hand strength to operate a DA revolver proficiently and that brings us to the striker fired pistols.
A single stack Glock such as the Glock Model 43 is about as close to the snubnose DA revolver concept as you can get. It is point and shoot and the trigger is easier to master for some females. When carried in an appropriate holster that covers the trigger, it is perfectly safe and still quick to deploy.
Training is key.