Wondeirng is this is a minor nusance that can mostly impact reliability or accuracy, or can a round touched off while the cylinder is not in line with the barrel lead to a catastropic failure?
I've always assumed that if the chamber was "in-line" enough for the primer to detonate, then the forcing cone would allow the clyinder and/or bullet to realign, possibly at the expense of spitting some lead and loosing some accuracy. Now I'm not so sure, especially if I imagine a bullet with a large meplat. Seems like in some cases, this could cause a pressure spike.