The twist /rev horse is pretty much beat to death so let's go ahead and move past that .
I know everyone knows it's length not weight and some aerodynamic weight distribution factors involved in making a bullet go in a straight (parabolic curve) line to arrive at the sighted point every time . So let skip over that also .
Presuming that a person designed every load around 1.4 MOA /1.5" and is attainable within a desired terminal effect at impact would you shoot a bullet of the light end , nominal for cartridge or the maximum or near maximum for the particular arm ?
Simplified version .
Per cartridge would you rather shoot light , normal , heavy weights .
If heavier is chosen would you get all the way to the limits ?