A good friend and I have debated the perfect suppressed set up for quite a few years. Given the low velocity needed, we figured a 429 to 454 cal would be the best, along with a large meplat. He decided to submit his paperwork for a 45 cal can this week. 500 s&w is ruled out because most of the 50 cal cans are for the bmg, big and expensive. He is looking at an encore bbl chambered in 45 colt from mgm. I figured I could make some dummies for mgm to throat the bbl for optimum fit.
I like the 350 gr noe mold, but it isn't in the files I downloaded to quick load. I figured it wouldn't be too hard to push this boolit to 1050 fps in an encore. It would be over saami pressures, but I don't think that would be a problem in an encore.
We debated the 300 whisper and ruled it out, based on a 30 cal maybe tumbling, maybe not. The idea is for a relatively short range, reasonably quiet thumper that would give good penetration and maximum leakage on deer, pig, and black bear sized critters.
He's looking at an m4 style grip for the encore, along with the sig brace to build a psuedo sbr that would be in compliance with current atf rulings and still be compact, maybe a 10" bbl.
Anxiously awaiting the thoughts from this knowledgeable group.