I seem to do pretty well, velocitywise, with the non Plus P loads in 38 such that when controllability in repeat fire is factored in with the light weight and shortish grip present in my 638, that's where I figure I should be at.
Ed Harris's "full charge wadcutter" suggestion of 3.5 Bullseye does around 780 with the Lee tumble lube wadcutter, with the same amount of Titegroup going maybe 5 to 10 fps faster.
It takes a couple of tenths more of Herco to equal whatever Unique does. With Alliant's non plus P suggestions as currently posted Power Pistol outruns the rest of the pack in both Plus P and non Plus P loadings.
Have not tried any BE 86 yet. Understand it may give similar performance to PP with somewhat less blast.
In terms of giving acceptably low velocity variation from powder position variation Titegroup does work well as long as bullet seating depth is not much shallower than a 158 provides. The top end speeds are somewhat lower, though, and Plus P loads are necessary to get velocities others like Power Pistol attain at standard pressures. If ballistic consistency is desirable that may be the way to go for low volume shooting use.
For any and all practice I see my 638 as a "standard pressure only" gun, both in terms of comfort for long practice sessions as well as "easy on the gun." Yeah, it is plus P rated, but sometimes less is more.