Yes. I have many .45 Colt's and many .44 magnums and .44 Specials. Years of effort tying hard to get my .45 Colt's to shoot as well as my .44 Magnums and .44 Specials have me agreeing with Elmer Keith: I quit the .45 Colt's! Just about any haphazard .44 load I throw together beats my carefully constructed .45 Colt's loads.