Respectfully disagree. From a ton of experience. With respect to everything you suggest about H110. All of it.
Regarding a straightwall 45 caliber case, whether 45 colt, 454 casull, or a 460 S&W, the response is the same with H110. Simply put: if you have a 45 colt ruger-only load with a 300 grain bullet that uses 24 grains of H110 with an OAL of 1.7 inches (fake numbers), then if you load it all the same with a 454 case, you have the same ruger load. Just the case mouth is .1" farther up the bullet. You can do exactly the same in a 460 S&W case though it'll look goofy to have the bullet seated below case mouth!
Crimping in a groove is not needed as long as you pick a bullet heavy enough to have lots of shank. Engagement surface with the case keeps things in order nicely.
As for light for caliber, H110 is great for that. Massive fireball and warp-ridiculous bullet speed. 454 is made for it, so is 460 S&W. My 460 can go over 2500 fps with a barnes 200 grain XPB and 52 grains of H110. The fireball is absurd.
H110 is also great for heavy-for-cal. I've gone as high as 590 grains with H110, but I'm sure I can go higher. Just no point. I have no doubts 454 would do GREAT with a 400+ grain bullet with H110.
Finally, H110 is fine to download. If (and this is a critical if!) you put the bullet down on the powder, you are GTG. H110 is dangerous to download when there is air inside the case. The more, the worse off you are. Just a little bit, and you will squibb all over the place. Very dangerous! You can correct that by seating deeper. That let's you download as far as you want and get 100% reliable ignition. The cost of that is you can't
crimp in the crimp groove. This is not a problem if you have a mile of bearing surface (like you do for a 350+ grain 45 cal)
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I made a simple tool to measure powder in cases.
bands are .100" apart exactly.
Sitting in a charged case. I now know exactly how far to seat the bullet to achieve 100% case-fill, 0% air in the case, and 0% powder compression. Exactly what you want for perfect performance from H110, every time. Regardless if you are using a low charge or a high charge of it.
I do always use magnum primers, but regular primers have only given me issues with AA#9 downloaded. Of course, that was back when I still thought I always had to use the crimp groove of a bullet. Now I know better.