Yeah I had a 45 Colt Rossi with that safety and it basically stayed out of the way when left off. My Marlin 45-70 with a cross bolt safety is more trouble because it seems to get bumped to On easier. But the 45 Colt Rossi had no trouble getting 300 grains to 1600 FPS. I got a nice 11 pointer with that load, it showed up behind me and I had to freeze with my head cranked all the way to right because he saw me up in the tree. He finally walked by next to my tree and it worked out my way.