Rosewood
No it doesn't happen with small charges of easily ignited powders as they burn fast enough to keep pushing the bullet forward. I'm sure some here have experienced, with extremely light loads, a bullet sticking in the barrel and the gas pressure being released back around the non expanded case.....or it the case is expanded the pressure being released when the action is opened. Small amounts (not to be confused with a "reduced load") of powder in such loads you mention do not contain the energy potential to create catastrophic amounts of pressure in a 45 Colt especially since the pressure is vented via the barrel/cylinder gap. However, at least two S.E.E.s have been documented in 45-70 Contender pistols with 300 gr jacketed bullets and relatively light loads of 2400.
Larry Gibson