I think a theme of this thread is that handguns are personal. One person's ultimate handgun might be a chrome plated semi auto with mother of pear grips. Someone else might love a color case hardened single action. Which is better? It is not for me to say. Same with grip frame style.
I have tried to think how a test of grip frame styles could be conducted. Have a master shooter try each type of grip on identical guns? Have the same shooter try the same gun with the same loads but swap grip frames and repeat the tests?
You would still be looking at a human factor. Maybe a fixture that would hold the guns exactly the same for each shot and then swap frames?
Those of us on this forum are here to some degree because we have opinions about what we like and what works for us in our guns. We try different boolits, loads, powders, sights, and grips to find what works for us. It is a personal thing.
I have no doubt that .44 Man could shoot rings around me with each of us shooting our favorite guns. That would only show that he is a better marksman than I am and will likely ever be. After getting my butt kicked I would still like Bisley grips on my Rugers and would still respect .44 Man and appreciate his posts and the things he has taught me on this forum.