I really like the old Colt Case. I do think about all of them could benefit from a custom cylinder, there are a LOT of sloppy chamber and throat dimensions out there. Not to mention forcing cones.
I've had similar thoughts about the Schofield Case and med. frame Blackhawks and Vaqueros, but every time I dwell on it, my practical side just keeps coming back to a .44 Special (granted, .44's make for heavier guns).
At the end of the day, I just have a hard time understanding what it is that a Colt case can't do that everyone wants it to.
Don't get me wrong, I'd love to see it done just so I could know! Someday I'll have a short, light, worked over Vaquero and I'd love to see this angle covered.