Mine was an 870 express 12 gauge with a rifled slug barrel that accounted for a lot of deer when I lived in Indiana, and I'd switch barrels out to a smoothbore for rabbits and turkey when deer season was over.
Now that I'm back south of the Mason-Dixon Line, my go-to is a LH Savage 11 in 300 WSM. The 300 WSM is a bit of a case of overkill for deer, but the rifle was a gift from my dad and it's accounted for quite a few deer here in SW Virginia..