I'm a huge fan of the 480, but unless you add moose and brown bears to the mix, I'd say the 44 and 45 are just as capable.
If I was to do it all over with what's currently available, I'd be hard pressed to pass up the 45 bisley convertible.
It does suffer the typical Ruger malady of needing a trigger job, but from a very short initial range session it seems like even with the heavy trigger to be a great shooter with either 45 acp or 45 colt. Something to be said for accurate mild practice loads with 200 gr swc 45 acp, and the 45 colt being loaded up to whatever level you deem necessary. I figure my wife's bisley will likely end up with a 454640 flat nose over 10 gr of unique for a working load, though I'll likely pick up a 300+ gr mold for heavy loads.
That said, the 480 srh has been the most accurate revolver I've every shot, and as mentioned 400 gr @ 1200 fps is at the same shootable recoil level of a 44 with 300's or a 45 with 330's. I've shot enough 475's and 500's to know adding a wee bit more lead and powder results in a level of recoil that is at a different level and is much more difficult to master. That and if 400 gr @ 1200 fps isn't enough, I'll take a rifle thank you very much!