When first working up a load (mostly rifle) I have at least a 100 cases that are within a accepted weight variation depending if it is a hunting rifle or a target rifle. I then load 50 rounds starting 10% below the maximum powder charge with 5 rounds while working up in 1% increments of a greater powder charge for 5 rounds each till I have all 50 rounds loaded. This will give me 10 loads of 5 shots each that will be shot at 100 yards. After going over the group sizes and chronograph data I determine what is close to the best load and will now load at least 20 rounds of each and now test at 200 yards. The testing at 200 yards will be 4 groups of 5 shots each, because shooting 5 shots and taking a short break between will allow the level of concentration to be maintained. Now the best load will be tested at 300 yards again with 4 groups of 5 shots each playing with seating depth. When this is done I start shooting 10 shot groups and then 20 shot groups.