LGS has had no problem keeping 4227 powder on the shelf but I've never used it. I'm working on load development for the 300 Savage, 35 Rem and 35 Whelen and also load for 30-30, 32 WS, 30-06 and 45 Colt. Looks like it would work for my 45 Colt hunting loads in place of 296 but I was wondering if it would work in place of 2400 for my plinking loads in 32WS and 30-30. Not much data for 4227 in the rifle cartridges I load but my shooting buddy loves it in his 22 Hornet.