Another 22 fan here. Even for the biggest steers.
I did shoot one of our goats with my 380 last year (its what I had on me) with 100gr cast and 3gr Bullseye. WAY over kill.
If your standing over her, aim for B but aiming slightly forward. If your behind her, shoot between A and B and aim for the nostrils. Its not hard to do. Your over thinking it. If your friend takes repeated shots, then he needs to learn where the brain is.
Light the BBQ.