I have noticed in some threads people mentioning about their defense loads. Now I am not an expert. Massad Ayoob is. For those that have never heard of him, he has been published in many magazines as well as having several books including the gun digest guide to concealed carry. He was a police officer and is considered an expert witness and has appeared many times in court for police and civilian cases in that capacity.
In his guide to concealed carry he addresses handloads for defensive carry as a very bad idea for a few reasons. Reason number 1, in a self defense carry shooting you are not disputing you shot the other person, but you have to prove it was in self defense. Crime labs use ballistics from factory ammo only. So say for instance you and an attacker were struggling, close up, and you managed to get the gun to his head and shoot him, but the angle was from the back of his head. The crime lab will test powder residue and will use factory ammo as a baseline. They will not use other ammo left in the gun and they will not use ammo from your home. Anything you made is considered tampered with. So they test the factory ammo and based on that they find that the gun wasn't inches away, but a few feet away making it look you shot an attacker in the back of the head as they were fleeing. That is just a rough outline of the case he cited in the book.
Also something to think about is the prosecution, civil and criminal. By using your own handloaded ammo and specially your own cast bullets it is possible for the prosecution to say that factory ammo wasn't good enough for you. That you had to make your own "special" killer ammunition and specifically set out to kill anyone you shot, that could be construed as premeditation.
In all the recommendation was use what the police use. I know speer gold dot is a good defensive load and is used by police. So should I ever need to use my weapon in self defense I am covered in that the lab can use any box of ammo I used off the shelf and get the same result in testing. And that since I was using the same ammo as law enforcement they can't get me for using "super bullets".
Just something to think about. The book is a very good read as are Massad's other works.