I assume the answer to this question is ...whatever works for you !
in most pictures of other peoples molds the sprue lever and handles are on the same end. My handles are on opposite ends ( I have a few Lee 6 Bangers)
I like to take the wood handle off the cam lever and use my "Bully " stick to smack the lever and cut the sprue.
I guess it just works better for me that way, but is there any specific reasons everyone else is wrong?