Believe me that when you start to use large cases with small bullets you will hit a brick wall of returns. A friend build a 6MM-06. And it turned out to be very touchy with pressure. And he did not get much in the way of more speed due to this. Not to mention throat erosion would be tremendously increased. He did just as well with a .243 Winchester Ackley Improved. I believe he was getting around 4100 FPS or so from a Hornady 58Gr Z Max.