First lathe I ever laid my hands on was a 17 x 57 Cincinnati Hydrashift. It seemed like a monster, until I had to rough some 4 inch dia. stainless down to 3 inch. Which was done on a circa 1937, 19 x 80 Lodge & Shipley. Overhead chain fall for changing chucks, steady rest or follow rest.
Like Randy says, horsepower, mass and rigidity are your best friends. Also, I can't imagine not being able to use 5C collets. Also, when single pointing a thread, even the smallest amount of chatter will destroy the cutting edge of your toolbit and show on the finish of your threads.
smokeywolf