I used 2400 in a 45 acp, with I believe a 260 gr bullet for a 45 colt, shot as cast. I saw they were listing a load for a 45 rimmed using 2400. load seemed more powerful than a normal 45 acp. 2400 will work, but maybe needs a 250 gr bullet. You do want a 30lb spring with this load because it develops substantial recoil.