A few years ago, I used a 686 with a 6" barrel and iron sights to harvest a couple of does. I used 158 gr. jacketed soft point. The first deer was a smaller one that I spine shot at 15 yards. The big girl I took was at 60 yards. It was a heart/lung shot. She ran approx 50-60 yards and dropped within sight of my stand.
My advice to you is to know your own limitations with the revolver. Practice at different yardage and from different positions until you are confident. You can't imagine how excited and nervous (and shakey) you will get when that deer comes within 50 yards or so and presents a shot. Even if you are an experienced hunter with a rifle, the revolver makes for a heart-pounding experience.