Use 4759 powder. You can get powerful loads with 4759 but you can't overload the .500 with it. You can't load it "too light" either. It doesn't hurt to compress it. Don't use ANY OTHER POWDER until you have gained some experience loading the .500 and have a clearer idea of what you really want to accomplish.
Get your mold from
www.mountainmolds.com Use their online design page (link at top left of home page) to create a mold based on the recommendations I give at
http://john-ross.net/sw500.php
The above advice will give you safe, accurate loads with the .500, right from the get-go, and they can be light, medium, or powerful, as you see fit.
If ordering a custom mold is too expensive or too much trouble, buy any mold that casts .501" diameter bullets and load the slugs with 4759. When you get some bullets in hand, give me the specs on them and I'll give you loading data.
I haven't shot bullets cast from every factory mold out there, but I will say this: The X-Frames are built as well or better than any DA revolver ever made, and almost every cast bullet I have ever fired from the .500 was accurate if sized .500" to fit the chamber throats. The only exceptions were super heavyweights (really long bullets) loaded to low-to-medium velocities when fired in the 1:18" twist barrels of the standard factory guns.
Good luck and have fun with that monster!