The Sierra 170gr JHC .41 bullet has been called tough, I put one through a small deer at the diaphragm. Didn't blow a big exit hole, but it didn't expand and stop in whatever amount of fluids it met. 14.5gr of 800x gets that bullet 1550-1600fps in handguns with 6.5-7" barrels, I did not check the load in the 10" T/C Contender barrel I used for that deer, but it had to be moving pretty quick. I also shot a somewhat larger doe with that bullet, but the angle from my tree stand was steeper than I allowed and she ran off a short distance and laid down. I had to creep up and shoot her in the neck to finish that one. The original shot raked the ribs low behind her foreleg, I don't think any bullet would have been a good killer with that shot. If the light .44 version of that bullet is constructed similarly I'd use it.
I've used .41's from Sierra, Speer and Hornady on deer, will carry cast until I get another chance with a handgun.