What I noticed when I resized the cases was that the die met more resistance at the bottom 1/2" or so on the case.
That is normal if the pressure is sufficient to obturate the case at that point. That area of the case is called the "web" and has thicker brass than the case fartherer out. It is also harder (not annealed) in that area. You might back the FL die out of the press so it sizes the cases only enough for reliable chambering. It will still be sized enough for good bullet tension. That will ease the harder sizing in the web area, work the brass less and give longer case life.
There is no "powder detonation", the powder ignites and burns. The 2400 powder is a relatively fast burning powder but may not be the best choice for 320 gr cast bullets in the 45-70, even with a Dacron filler. The problem could be as simple as the bullet mass is not enough for 2400 at 24 gr to burn efficiently for it to give good accuracy. I suggest working up to 27 gr, with and with out the Dacron filler. If that doesn't work you might switch to a powder such as Unique.....that's the powder I prefer for my 300 gr PB cast bullet loads in my 45-70s. TB may work better also.
When using Dacron as a filler make sure it is a filler. In post #2 I explain it;
http://castboolits.gunloads.com/show...use-of-fillers. If you have read it and are using the Dacron filler correctly then it's the powder or charge of powder that is probably the problem.